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Coronavir.org

Site de veille et d'information sur le nouveau coronavirus SARS-COV-2 et la maladie associée COVID-19

Actualités et recherches en cours

SARS-CoV2 is highly contagious and the global spread has caused significant medical, social and economic impacts. Other than vaccination, effective public health measures, including contact tracing, isolation and quarantine, is critical for deterring viral transmission, preventing infection progression and resuming normal activities. Viral transmission is affected by many factors but the viral load and vitality could be among the most important ...

Researchers in the USA have developed a novel strategy that redirects antibodies developed against hepatitis B virus to the spike proteins of SARS-CoV-2. They propose using peptide-based double-faced “booster” inhibitors, with one face binding to the spike proteins of SARS-CoV-2 and the other face binding to antibodies developed against hepatitis B virus. Molecular dynamics simulations revealed that the designed boosters have a highly specific an...

The UK has had a volatile political environment for some years now, with Brexit and leadership crises marking the past five years. With this work, we wanted to understand more about how the global health emergency, COVID-19, influences the amount, type or topics of abuse that UK politicians receive when engaging with the public. With this work, we wanted to understand more about how the global health emergency, COVID-19, influences the amount, ...

Although nasopharyngeal (NP) samples have been considered the gold standard for COVID-19 testing, variability in viral load across different anatomical sites could theoretically cause NP samples to be less sensitive than saliva or nasal samples in certain cases. Self-collected samples also have logistical advantages over NP samples, making them amenable to population-scale screening. To evaluate sampling alternatives for population screening, we...

In May 2020, the first stage of the Adaptive Covid-19 Treatment Trial (ACTT-1), a randomized, double-blind, placebo-controlled trial, showed that remdesivir is an effective treatment for hospitalized adult patients with coronavirus disease 2019 (Covid-19) pneumonia. Despite the benefits of…...

The clinical course of coronavirus disease 2019 (Covid-19) is characterized by an initial stage with mild symptoms of the upper respiratory tract. During this stage, the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peaks, with progressive lowering afterward. After 7 or…...

The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…...

The clinical trials of the Pfizer–BioNTech and Moderna vaccines involved two injections given 3 to 4 weeks apart. Both vaccines had approximately 95% efficacy after the second dose — an impressive finding. Under normal circumstances, the vaccines should be deployed in keeping with the trial…...

As U.S. states have developed guidelines for Covid-19 vaccination, some have moved to include "paid or unpaid caregivers (including parents or foster parents) of medically fragile children or adults who live at home" in Phase 1 vaccine allocation. This policy decision is stunning in its…...

BackgroundSustained molecular detection of SARS-CoV-2 RNA in the upper respiratory tract (URT) in mild to moderate COVID-19 is common. We sought to identify host and immune determinants of prolonged SARS-CoV-2 RNA detection. MethodsNinety-five outpatients self-collected mid-turbinate nasal, oropharyngeal (OP), and gingival crevicular fluid (oral fluid) samples at home and in a research clinic a median of 6 times over 1-3 months. Samples were te...

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