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Site de veille et d'information sur le nouveau coronavirus SARS-COV-2 et la maladie associée COVID-19

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Definition of SARS-CoV-2 antibody responses is essential to verify protective immunity following infection and vaccination. Here, we devised a versatile serological test, named ABCORA, that is based on a multifactorial analysis of SARS-CoV-2 and circulating human coronavirus (HCoV) antibody responses. Utilizing empirical tailored cut-offs and computational approaches based on training and validation cohorts comprising pre-pandemic (N=825) and SA...

Both SARS-CoV-2 infection and vaccination elicit potent immune responses. A number of studies have described immune responses to SARS-CoV-2 infection. However, beyond antibody production, immune responses to COVID-19 vaccines remain largely uncharacterized. Here, we performed multimodal single-cell sequencing on peripheral blood of patients with acute COVID- 19 and healthy volunteers before and after receiving the SARS-CoV-2 BNT162b2 mRNA vaccin...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections caused more than 83 million known cases of coronavirus disease 2019 (Covid-19) by the end of 2020, but tremendous progress has been made with the authorization and deployment of vaccines and antibody therapies. These strategies…...

Background Vaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings. Methods A cohort study of 805 741 residents in Scania county, Southern Sweden, aged 18-64 years, of whom 26 587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with substantial community spread of the disease. Results T...

Widespread vaccine hesitancy in Ukraine threatens the success of the country's COVID-19 vaccination programme. Edward Holt reports....

Scientists have shown that SARS-CoV-2 can make itself unrecognisable to cytotoxic T cells (so-called T-killer cells) through mutations. Whereas antibodies dock directly onto viruses to render them harmless, T-killer cells recognise viral protein fragments on the surface of infected cells and subsequently kill them to stop virus production. The study found that mutations in SARS-CoV-2 decreased binding of viral fragments to host proteins responsib...

The first coronavirus disease 2019 (Covid-19) vaccines available in the United States were messenger RNA (mRNA) vaccines: BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna). In December 2020, the vaccines were granted Emergency Use Authorization (EUA) by the Food and Drug Administration (FDA) as a…...

This Medical News article discusses attacks against health care workers since the COVID-19 pandemic began and ways to prevent some of these incidents....

The Original Investigation titled “Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy,” published April 6, 2020, has been corrected to include the nonauthor collaborator (group) names in a supplement....

As DR Congo and Guinea experience concurrent Ebola and COVID-19 outbreaks, the countries face the challenge of vaccinating people against both. Paul Adepoju reports....

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