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Coronavir.org

Site de veille et d'information sur le nouveau coronavirus SARS-COV-2 et la maladie associée COVID-19

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Researchers have discovered how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, can block the production of cellular proteins and contributes to severe illness in its host. Previous studies had implicated a viral protein, nonstructural protein 1 or Nsp1, in the virus’ ability to block cells’ production of new proteins. The researchers were able to show that Nsp1 is one of SARS-CoV-2's most pathogenic ...

The National SARS-CoV-2 Serology Assay Evaluation Group. Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison. Lancet Infect Dis 2020; 20: 1390–400—In this Article, the equivocal results for the DiaSorin assay had been incorrectly included in the sensitivity and specificity analyses. The values for the DiaSorin results have been updated in the Summary, table, figure 1, figure 4, and the appendix. Ad...

The COVID-19 pandemic dominated the topics discussed at the first virtual annual IDWeek conference in October. Farooq Kazi and Ammara Mushtaq report....

Background The novel coronavirus, SARS-CoV-2, has increased the burden on healthcare systems already strained by a high incidence of tuberculosis (TB) as co-infection and dual presentation are occurring in syndemic settings. We aimed to understand the interaction between these diseases by profiling COVID-19 gene expression signatures on RNA-sequencing data from TB-infected individuals. Methods We performed a systematic review and patient-level m...

Fine scale delineation of epitopes recognized by the antibody response to SARS-CoV-2 infection will be critical to understanding disease heterogeneity and informing development of safe and effective vaccines and therapeutics. The Serum Epitope Repertoire Analysis (SERA) platform leverages a high diversity random bacterial display library to identify epitope binding specificities with single amino acid resolution. We applied SERA broadly, across ...

Background: Whether diabetes is associated with COVID-19-related mortality remains unclear. Methods: In this retrospective case-series study we examined the risk of death associated with self-reported diabetes in symptomatic adult patients with laboratory-confirmed COVID-19 who were identified through the System of Epidemiological Surveillance of Viral Respiratory Disease in Mexico from January 1 through November 4, 2020. Survival time was right...

Human Challenge Trials (HCTs) are a potential method to accelerate development of vaccines and therapeutics. However, HCTs for COVID-19 pose ethical and practical challenges, in part due to the unclear and developing risks. In this paper, we introduce an interactive model for exploring some risks of a SARS-COV-2 dosing study, a prerequisite for any COVID-19 challenge trials. The risk estimates we use are based on a Bayesian evidence synthesis mo...

It’s time to change how we think about the sensitivity of testing for Covid-19. The Food and Drug Administration (FDA) and the scientific community are currently almost exclusively focused on test sensitivity, a measure of how well an individual assay can detect viral protein or RNA molecules.…...

The only way out of today’s misery is for people to become worthy of each other’s trust. — Albert Schweitzer As the race to develop a vaccine for Covid-19 has reached phase 3 clinical trials, concerns are increasing about the low rates of trial participation in important subgroups, including Black…...

During previous public health emergencies, the issue of whether public health agencies should recommend that women avoid becoming pregnant because of potential risks to themselves and their newborns has been controversial. The ongoing Covid-19 pandemic has again led to questions regarding whether…...

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