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Site de veille et d'information sur le nouveau coronavirus SARS-COV-2 et la maladie associée COVID-19

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As a minority of countries consider offering booster doses of COVID-19 vaccines to their citizens, the majority are yet to vaccinate their entire populations with a single dose. Talha Burki reports....

As we reported in an Editorial in January, the goals set to reduce malaria incidence and mortality by 2030 seem unlikely to be met at current rates of progress. Furthermore, COVID-19 could have a damaging effect on malaria control by delaying prevention measures designed to combat seasonal peaks in disease transmission. However, amid concerns about missed targets and pandemic setbacks, recent results of clinical trials offer hope for reinvigorati...

Essential infectious diseases services, including COVID-19 vaccination programmes, have been disrupted by the Taliban takeover of Afghanistan. Sanjeet Bagcchi reports....

Researchers have found that SARS-CoV-2 is prevented from docking and invading the body's cells only when people are able to form specific antibodies against the folded receptor-binding domain (RBD) of the spike protein, and this docking site does not change with significant virus mutations. The researchers used microarray or chip technology, in which a large number of viral antigens were applied to a microscopic chip by a robotic spotting machine...

Rising cases of the SARS-CoV-2 delta variant despite strict lockdowns in parts of Australia have led authorities to reconsider control strategies in the country. Georgina Kenyon reports....

Clinicians might have a new tool to predict which patients who test positive for SARS-CoV-2 will remain asymptomatic and who will develop symptoms. A study showed that low blood levels of a lipid, sphingosine, are linked with development of COVID-19 symptoms. High levels of the lipid and a protein used in its production, acid ceramidase (AC), were associated with asymptomatic infections, and some 75% of asymptomatic patients had high AC levels. U...

It was around Thanksgiving last year. The American journalist and author of multiple books, Nina Burleigh, got a call from Dan Simon, founder and publisher of Seven Stories Press, asking whether she could recommend someone to write a fast turnaround book tracing the race for COVID-19 vaccines. The call could not have been timed better. The USA crossed 4 million COVID-19 cases in November alone. The Presidential elections were over, and Donald Tru...

Abstract Background: Following emergency use authorization in December 2020, the Coronavirus Efficacy (COVE) trial was amended to an open-label phase, where participants were unblinded and those randomized to placebo were offered vaccination. Emergence of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with increased incidences of coronavirus disease 2019 (Covid-19) among unvaccinated and vac...

Waning serum antibodies against SARS-CoV-2 have sparked discussions about long-term immunity and need for vaccine boosters. We examined SARS-CoV-2 spike IgG antibodies in a longitudinal cohort, comparing antibody decay in individuals who received an mRNA SARS-CoV-2 vaccine, with and without prior SARS-CoV-2 infection. We completed a longitudinal cohort of healthcare workers (HWs) between June 2020 and September 2021. HWs were included if they ha...

Ethnic minorities in developed countries suffer a disproportionately high burden of COVID-19 morbidity and mortality, and COVID-19 ethnic disparities have been attributed to social determinants of health. Vitamin D has been proposed as a modifiable risk factor that could mitigate COVID-19 health disparities. We investigated the relationship between vitamin D and COVID-19 susceptibility and severity using the UK Biobank, a large progressive cohor...

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