Logo Coronavir.org

Coronavir.org

Site de veille et d'information sur le nouveau coronavirus SARS-COV-2 et la maladie associée COVID-19

Actualités et recherches en cours

As the world marks the 40th anniversary of the HIV/AIDS epidemic, we ask what impact the COVID-19 pandemic is having on HIV programmes around the world. Talha Burki reports....

The SARS-CoV-2 pandemic has many parallels to the early days of the HIV epidemic. Both began with efforts to identify the causative pathogen, followed by rapid development of diagnostics, animal models, therapeutics, and preventive vaccines. After targeting of the gp120 and gp160 HIV envelope proteins proved ineffective, development of candidate vaccines to prevent HIV expanded to encompass DNA and viral vector vaccines, with the intent of induci...

Researchers have documented an unexpectedly frequent occurrence of acute transverse myelitis (ATM)— inflammation of the spinal cord—in 43 patients with COVID-19. A review of the literature found that patients from 21 countries developed spinal cord lesions after contracting the virus. Symptoms included paralysis and sphincter or bowel dysfunction. The patients’ ages ranged from 21 years to 73 years. Three ATM cases were reported during trials of ...

“Those who do not learn history are doomed to repeat it”, wrote the renowned Spanish philosopher George Santayana. While the COVID-19 pandemic may have taken many by surprise and made us all too aware of the invisible enemies with which we share the planet, the truth is that microorganisms have posed an ever-present danger throughout the history of humanity. With this in mind, author Salvador Macip believes that only by learning the history of th...

Low uptake in Russia of the country's domestically manufactured COVID-19 vaccine Sputnik V reflects systemic mistrust in vaccination and the state health-care system. Ed Holt reports....

Background. Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SAR2-COV-2) that identified first in Wuhan, China, in December 2019, rapidly spreading to the rest of the globe, becoming a pandemic. Some studies have eluded to an association between pregnancy status and severe COVID-19 cytokine storm, some, in contrast, have demonstrated such. The aim of the current study was to find the relationship ...

Importance: Contact-tracing studies suggest minimal secondary transmission in schools. However, there are limited school data accounting for asymptomatic cases, particularly late in the 2020/21 school year, and in the context of uninterrupted in-person schooling and widespread community transmission. Objectives: To determine the SARS-CoV-2 seroprevalence in a sample of school staff, compared to the community, and to COVID-19 rates among all stud...

Background The success of early dexamethasone therapy for hospitalised COVID-19 cases in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action against a hyperinflammation (HI) response. It is likely that there is substantial heterogeneity in HI responses in COVID-19. Methods Blood CRP, ferritin, neutrophil, lymphocyte and platelet counts were scored to assess HI (HI5) and combined with a validated measure of ge...

Background: Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential therapeutic, but there is limited data for patients with moderate-to-severe disease. Research Question: What are outcomes associated with administration of CCP in patients with moderate-to-severe COVID-19 infection? Study Design and Methods: We conducted a propensity score-matched analysis of patients with mode...

Background: The pandemic of coronavirus disease 2019 (COVID-19) represents a great threat to global health. Sensitive tests that effectively predict the disease outcome are essentially required to guide proper intervention. Objectives: To evaluate the prognostic ability of serial procalcitonin (PCT) measurement to predict the outcome of COVID-19 patients, using PCT clearance (PCT-c) as a tool to reflect its dynamic changes. Methods: A prospectiv...

Important : Le contenu diffusé sur Coronavir.org ne doit jamais remplacer les conseils d'un médecin ou des autorités de santé locales.