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Coronavir.org

Site de veille et d'information sur le nouveau coronavirus SARS-COV-2 et la maladie associée COVID-19

Actualités et recherches en cours

In their active surveillance study of patients with COVID-19 in south India, Ramanan Laxminarayan and colleagues1 reported an increased risk of death in patients who had a history of diabetes (adjusted hazard ratio 2·28, 95% CI 1·79–2·91), hypertension (2·08, 1·62–2·66), other circulatory disorders (3·89, 2·66–5·71), cancer (8·04, 3·47–18·65), or respiratory disorders (4·57, 2·43–8·61). Male sex, older age, and chronic kidney disease were also as...

In a strange quirk of fate, when Wolfgang Preiser worked in Frankfurt, Germany, back in 2003, he was part of the team that isolated the aetiological coronavirus new to humans from the first SARS patient in Germany. Fast forward almost two decades to the COVID-19 pandemic, and Preiser is part of the team who discovered, in November 2020, the beta variant of SARS-CoV-2 and a year later the omicron variant, which just 2 months later is dominant almo...

A new report outlines the extent to which the COVID-19 pandemic has disrupted education services across the world. Talha Burki reports....

In their Personal View on the European clinical research response to COVID-19, Herman Goossens and colleagues1 provide relevant recommendations for a future perspective for the pandemic research response. As a European public funder, we add complementary views below....

Herman Goossens and colleagues1 call for structures and partnerships to enable clinical research and identify regulatory hurdles among the challenges for clinical trials. As European regulators, we acknowledge the need to optimise the clinical trials environment in Europe. Here, we outline tools to address the challenges and highlight a new EU initiative, Accelerating Clinical Trials in the EU (ACT EU), that will enable faster, bigger, and more r...

Joan B Soriano and colleagues1 proposed a clinical case definition for post-COVID-19 condition. We thank this WHO-led working group for their efforts to provide an operational definition for this emerging, challenging condition....

Scientists have identified a small group of rare structural gene variants found in people who are extremely ill with COVID-19 using optimal genome mapping of 52 patients. Seven such variants affecting 31 genes involved in innate immunity, inflammation, and other key pathways were found in nine of the sickest patients who shared common comorbidities such as diabetes and hypertension. The scientists say that more research is needed on the role of s...

With this issue of The Lancet Infectious Diseases, I thank the 985 individuals who submitted a peer review report for the journal in 2021 (944 subject reviewers and 41 statistical). During a second year in which the infectious diseases community has been focused on responding to the COVID-19 pandemic, I am grateful to all those people who have found time for peer review of their colleagues’ papers. Peer review remains an essential—if imperfect—pa...

ObjectivesIntermittent fasting boosts some mechanisms of host defense against infection while modulating the inflammatory response. Lower-frequency periodic fasting is associated with greater survival and lower risk of comorbidities that exacerbate COVID-19. This study evaluated the association of periodic fasting with COVID-19 severity and, secondarily, initial diagnosis of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-...

BackgroundPregnant persons are at increased risk of severe COVID-19 and adverse obstetric outcomes. Understanding maternal antibody response and transplacental transfer after SARS-CoV-2 infection and COVID-19 vaccination is important to inform public health recommendations. MethodsThis prospective observational cohort study included 351 birthing individuals who had SARS-CoV-2 infection or COVID-19 vaccination during pregnancy. IgG and IgM to SA...

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